However, upon intracranial infection with the LCMV Traub strain, which causes CD8+ T-cell-mediated immunopathology and meningitis in immunocompetent mice, CXCL10 expression seems to originate mainly from astrocytes, and CXCL10 strongly drives the infiltration of CXCR3+ CD8+ T cells into the meningeal compartment [143, 144]. The gene discussed is CD8A; the disease is infectious meningitis.