Of the 12 upregulated RAEC-associated genes, FSCN1 was ranked the top one by XGBoost (Fig. 2f), followed by TMEM255B and GABRD. Additionally, these 3 genes’ expression levels were significantly associated with PCa recurrence and higher Gleason scores (Fig. S6). This evidence concerns the gene FSCN1 and posterior cortical atrophy.