A total of 2457 ECs were annotated according to the expression of PECAM1, VWF, and ENG. We then leveraged the Scissor algorithm to integrate these ECs’ transcriptomics to the TCGA-PRAD cohort and reliably identified (P < 0.05) a subset of ECs (n = 347) whose expression profiles are associated with PCa recurrence. This evidence concerns the gene VWF and posterior cortical atrophy.