In addition, we identified individuals with ADHD with de novo damaging variants in the genes FBXO11, STAG1, and CTNNA2. These genes have high constraint (pLI) scores and have been previously identified as high-confidence risk genes for neurodevelopmental disorders9 (Table 1, Supplementary Data 2). This evidence concerns the gene CTNNA2 and attention deficit-hyperactivity disorder.