For instance, Ye et al. found that the predominant TAMs in orthotopic HCC in RBPj cKO mice showed characteristics of KCs, indicating that TAMs in situ in HCC probably come from embryonic hematopoiesis-generated KCs and BM monocyte-derived KCs, which are thought of as self-renewing tissue-resident macrophages [38–40]. Here, RBPJ is linked to hepatocellular carcinoma.