SLC39A8 and osteoarthritis: The highly pleiotropic variant, rs13107325_C > T, of SLC39A8 (solute-carrier family gene which encodes the ZIP8 protein), was associated with 14 UKBB and 3 GWAS Catalog phenotypes, replicating several known associations21 with hypertension, schizophrenia, Crohn’s disease, urinary incontinence, musculoskeletal system-related traits such as osteoarthritis and traits related to alcohol dependence.