According to our analysis of the cBioPortal datasets, high G6PD expression appears to be associated with poorer survival outcomes in lung cancer patients with co-mutations of KRAS and LKB1. Moreover, increased MTHFD1 mRNA expression levels are linked to unfavorable survival outcomes in lung cancer patients with wild-type KRAS, except for those with co-mutations of KRAS and LKB1. This underscores the significance of one-carbon metabolism in lung cancer. The gene discussed is G6PD; the disease is lung carcinoma.