HMGB1 and COVID-19: CD147 stimulation by SARS-CoV-2 via the spike protein S1 subunit stimulates platelets (monitored by the up-regulation of HMGB1, aggregation, granules discharge, shedding and release of P-selectin and release of platelet HMGB1+EVs), contributing to the early and intense activation of platelets found in COVID-19 patients and associating with fatal outcomes22.