BDNF and mental disorder: BDNF also gives trophic support for many neurotransmitters known to impact mental disorders (Croll et al., 1994; Hyman et al., 1991; Knusel et al., 1991; Mamounas et al., 1995), and human (Polyakova et al., 2015) and animal (Angelucci et al., 2005) data implicate BDNF in the response to psychotropic medications.