Intriguingly, early-onset DEEs were frequently observed for both individuals with GABRB2 and GABRB3 GOF, but while the peculiar epilepsy syndrome EIMFS was more prevalent in the GABRB3 GOF sub-cohort, EIDEE with a burst suppression pattern occurred at a higher frequency in the GABRB2 GOF group. The gene discussed is GABRB2; the disease is epilepsy syndrome.