The most regulated genes were Hist1h2ap (H2A clustered histone 23), encoding a replication-dependant histone of the H2A family, and Fos, encoding the Fos proto-oncogene implicated as regulator of cell proliferation and differentiation, both downregulated in the US group compared to non-treated ALS controls (Fig. 5b). Here, FOS is linked to amyotrophic lateral sclerosis.