The embryonic development of the heart is intricately regulated by numerous genes and signaling pathways, posing challenges for research into CHD pathogenesis.[55] Emerging evidence suggests that non-coding RNA play a role in regulating gene expression and may contribute to heart development.[56,57] Xiaochuan et al[58] demonstrated the involvement of the miR-125b/RASSF1 axis in cardiac myocyte apoptosis, with miR-125b directly regulating RASSF expression. The gene discussed is RASSF1; the disease is coronary artery disorder.