In the setting of high preoperative serum carbohydrate antigen-125 levels and concomitant endometriosis, postoperative administration of GnRH-a therapy reduces the risk of recurrence.[15] Combination therapy may also be considered: laparoscopy, GnRH-a therapy, assisted reproductive technology, and placement of levonorgestrel-releasing intrauterine system. The gene discussed is GNRH1; the disease is endometriosis.