When AD occurs, the arterial wall undergoes significant infiltration by macrophages, leading to structural damage.[23] Macrophage infiltration can severely compromise the structure of the aorta, ultimately leading to separation and rupture of the aortic wall.[15,22] The use of VEGFI may increase the risk of arterial dissection, potentially through inhibition of the phosphatidylinositol 3-kinase-AKT signaling pathway, leading to overexpression of matrix metalloproteinase 9 and exacerbation of extracellular matrix degradation. This evidence concerns the gene MMP9 and Alzheimer disease.