ATM and Ataxia-telangiectasia: Ataxia-telangiectasia mutated (ATM) is the product of genes lost in Ataxia-telangiectasia; ATM activation promotes autophagy, maintains the lysosomal-mitochondrial axis, facilitates cellular senescence, and inhibits apoptosis.[58] Increased Tumor protein p53 inhibits AMPK and promotes apoptosis.