NPPB and Miyoshi myopathy: Studies have shown that minimal residual lesions (MRD) in bone marrow can more sensitively and deeply reflect the depth of disease remission, and is closely related to the prognosis of the disease.[20] The study of Rios-Tamayo showed that NT-proBNP ≥ 8500 pg/mL was an independent prognostic factor for overall survival, while cardiac ejection fraction had a marginal effect.[21] In addition, age is also a very strong prognostic factor for AL and MM.