Long et al[2] reported that approximately 33.3% of patients with GFAP astrocytopathy have coexisting antibodies, such as N-methyl-d-aspartate receptor (NMDAR), Aquaporin-4 (AQP4), and myelin oligodendrocyte glycoprotein (MOG) antibodies, or their combinations.[3–5] Thus, the coexistence of autoantibodies in patients with GFAP astrocytopathy is common, referred to as the overlap syndrome.[6] However, there are no reports of GFAP astrocytopathy have been reported with positive NMDAR antibodies and sulfatide-IgG. This evidence concerns the gene AQP4 and connective tissue disorder.