DNM2 and neurodegenerative disease: The accumulation of ubiquitinated, aggregated proteins inmanyneurodegenerative diseases indicates altered, abnormal proteostasis.Abundant abnormal aggregates of cytoskeletal proteins are neuropathologicalsignatures of many neurodegenerative diseases and represent anotherhallmark of neurodegeneration related to all other degeneration attributes.9,10 Mitochondrial dysfunction is repetitively involved in the pathogenesisof diverse neurodegenerative diseases.