When a Gail Model Score was derived for the women at the age of their breast cancer diagnosis, n = 9 had a lower risk score for 5-year and lifetime risk of breast cancer compared to the US population mainly related to first birth before age 25 years, whereas n = 4 had a higher risk score mainly related to a first-degree relative with breast cancer (including the woman with the BRIP1 variant of uncertain significance), 1 was similar and n = 4 could not be calculated. This evidence concerns the gene BRIP1 and breast cancer.