Last, to mitigate concerns that the ectopic expression of CD74 may enhance CD4 activation irrespective of IRF8 status, and to define whether CD74 can rescue the IRF8-mutant phenotype, we tested CD74 effects on B cell lymphoma models expressing IRF8 WT, the DBD mutant N87Y, or the CTD mutant I424T. This evidence concerns the gene IRF8 and B-cell non-Hodgkin lymphoma.