Next, we ectopically expressed mouse Cd74 (p41 isoform) in the IRF8 KO A20, 2PK-3, and BCL1 B cell lymphoma models and showed that this genetic modulation was sufficient to rescue the defective OVA-elicited CD4 activation (IL-2 secretion and CD25 expression) associated with IRF8 KO (Fig. 5G and fig. The gene discussed is IRF8; the disease is B-cell non-Hodgkin lymphoma.