Tumor growth was significantly suppressed in IRF8-mutant lymphomas coexpressing CD74, while no difference was detected between IRF8 WT and IRF8 WT + CD74 (Fig. 6E); once more, only negligible differences were detected in in vitro growth rates supporting the role of the microenvironment in the differences detected in vivo (fig. This evidence concerns the gene CD74 and neoplasm.