These findings, together with defective expression of CD74 and HLA-DM, and the CD74-mediated rescue of IRF8-mutant lymphomas, suggest that of the many steps involved in the antigen processing/presentation cascade, IRF8 may impinge primarily on loading, and possibly not on acquisition, tagging, proteolysis, trafficking, and display (34). The gene discussed is HLA-DMA; the disease is lymphoma.