To test whether the IRF8 mutant–driven remodeling of the lymphoma microenvironment found in mouse models of B cell lymphoma could be recapitulated in primary human DLBCL, we used deconvolution of bulk RNA sequencing (RNA-seq) data (dbGaP Study Accession: phs001444.v2.p1). Here, IRF8 is linked to diffuse large B-cell lymphoma.