Tumor growth was significantly suppressed in IRF8-mutant lymphomas coexpressing CD74, while no difference was detected between IRF8 WT and IRF8 WT + CD74 (Fig. 6E); once more, only negligible differences were detected in in vitro growth rates supporting the role of the microenvironment in the differences detected in vivo (fig. The gene discussed is IRF8; the disease is neoplasm.