IRF8 mutations in DLBCL were mutually exclusive with mutation in a series of genes that are directly (CIITA, CD74, HLA-DMB, B2M, HLA-B, and HLA-C) or indirectly (CREBBP and EP300) involved with antigen presentation and/or remodeling of the TME (fig. The gene discussed is CREBBP; the disease is diffuse large B-cell lymphoma.