UBE3A and autism: We used the Ube3a2X mouse model (27, 32, 44), mimicking maternally inherited 15q11-13 triplication, to investigate how such a genomic risk factor interacts with sex to produce differential effects at connectomic, behavioral, and transcriptomic levels, i.e., Ube3a2X mice harbor two extra-copies of Ube3a transgene and exhibit deficits in cortical excitatory transmission, together with core autism traits of relevance for dup15q syndrome (27, 44).