Then multivariate logistic regression analysis was conducted and the results indicated that prealbumin [odds ratio (OR): 0.458, 95% CI: 0.239–0.874, P = 0.018], glucose (OR: 2.014, 95% CI: 1.095–3.705, P = 0.024), CEA (OR: 1.955, 95% CI: 1.082–3.532, P = 0.026), D-dimer (OR: 3.104, 95% CI: 1.446–6.663, P = 0.004) and platelet (OR: 0.574, 95% CI: 0.331–0.994, P = 0.0448) were independent markers for CRC metastasis (Table 3). The gene discussed is CEACAM5; the disease is colorectal carcinoma.