Considering that STAT1 signaling activation plays an important role in tumor cell metastasis via cell adhesion molecules induction (Marimuthu et al., 2022; Chen et al., 2019), it is highly plausible that MFGE8-L, but not MFGE8-S, impeded breast cancer cell motility and invasive capability in a STAT1-dependent manner. This evidence concerns the gene MFGE8 and breast cancer.