CD8A and neoplasm: Indeed, experimental ablation of IFNγ production by Tregs was associated with reduced treatment-induced accumulation of CD8+ T cells within tumors, which could indicate not only that Treg fragility is required for FS120m to exert its antitumor effects but also that it does so through providing proinflammatory signals that enhance tumor infiltration by cytotoxic CD8+ T cells, themselves also shown to have enhanced cytokine production during FS120m treatment.