Recent studies have highlighted that alternate receptors may be used for SARS-CoV-2 entry to the cells of the CNS, with neuropilin-1, CD147 and DPP4 reported as potential SARS-CoV-2 entry factors for astrocytes [27, 28], and that TMPRSS2 is not required for infection of neurons [29]. The gene discussed is TMPRSS2; the disease is infection.