TRAF6 and diabetic retinopathy: However, TRAF6 induced inflammation in human retinal microvascular endothelial cells (Lu et al. 2018) and human alveolar epithelial cells (Guo et al. 2015); loss of TRAF6 effectively relieved inflammation and prevented the development of diabetic retinopathy (Lu et al. 2018) and LPS-induced acute lung injury (Guo et al. 2015).