ETNK1 and multiple system atrophy: Notably, there was some overlap of the CpGs identified in the individual disease groups with the CpGs identified in the overall comparison, including CpGs in FAM8A1, C4orf50, and ETNK1. Interestingly, in line with the expected downstream effect of hypomethylation in the promoter region of BCL7B (cg15644686) on gene expression levels, a previous study on the transcriptional profiling of cerebellar white matter in MSA reported an average upregulation of BCL7B (fold-change = 1.49, adj.P = 2.4 × 10–2) in the two cohorts studied [56].