Among these differentially methylated CpGs, only cg15274294 (annotated as intergenic in the Illumina annotations, but found be a novel transcript [ENSG00000234261] associated with the lncRNA class and maps to the novel lincRNA RP11-146I2.1) and cg15644686 (BCL7B) in MSA, cg01380065 (UBE2F) in PD, and cg25358066 (D2HGDH) in PSP showed substantial effect sizes with absolute delta beta values ≥ 5% (Fig. 3); however, the direction of effect for these CpGs remained the same in all three diseases. The gene discussed is D2HGDH; the disease is Parkinson disease.