D2HGDH and supranuclear palsy, progressive, 1: The CpG cg25358066 (ExonBnd), found to be hypermethylated in with the strongest effect in PSP, mapped to D2HGDH (D-2-hydroxyglutarate dehydrogenase), a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family and an overexpression of D2HGDH has been demonstrated to inhibit ferroptosis [73].