Similarly, an EWAS in the prefrontal lobe tissue of PSP individuals identified increased methylation in DLX1, a transcription factor influencing MAPT expression, which might contribute to PSP pathogenesis and another study revealed several DNA methylation changes in the vicinity of PSP-associated loci, including MOBP [3, 74]. This evidence concerns the gene DLX1 and supranuclear palsy, progressive, 1.