MAPT and supranuclear palsy, progressive, 1: White matter abnormalities, such as demyelination, axonal loss, and gliosis, have been documented in all three neurodegenerative parkinsonian disorders, with significant white matter involvement being observed in MSA [15], tau pathology extending to white matter regions in PSP [66], and recent studies pointing toward white matter changes in PD playing roles in disease development and progression [77].