Multiple epigenome-wide association studies (EWAS) in Parkinson's disease (PD) have revealed significant DNA methylation changes in genes, such as CYP2E1, SNCAIP, and several others across various brain regions, implicating pathways, such as Wnt and Hippo, in PD pathology [13, 32]. The gene discussed is CYP2E1; the disease is Parkinson disease.