SCARF2 and multiple system atrophy: Other, notable hub genes specifically identified in modules correlating with α-synucleinopathies included C1orf70, which has been implicated to play a role in spinocerebellar ataxia, and SCARF2, which maps to the 22q11 deletion region previously associated with increased PD risk, suggesting that dysregulation of these genes might also be involved in the MSA pathogenesis [45].