WWOX, an AD risk gene also implicated in PD and multiple sclerosis [2, 29], has been shown to be responsible for Tau hyperphosphorylation resulting in aggregation of Tau into neurofibrillary tangles (NFTs), in addition to possessing pro-apoptotic properties, and its loss-of-function has been shown to result in the activation of a protein aggregation cascade [34]. Here, MAPT is linked to Alzheimer disease.