CD8 + T lymphocytes are involved in neuronal cell injury through the release of cytotoxic proteases (Gu et al. 2015), and CD4 + and CD8 + T cells can increase IS and brain injury after cerebral ischemia and reperfusion by increasing inflammatory responses and thrombosis (Yilmaz et al. 2006). This evidence concerns the gene CD8A and Cerebral ischemia.