REN and type 1 diabetes mellitus: The KEGG analysis indicated that the up-regulated genes were relevant with Staphylococcus aureus infection, Viral myocarditis, Type I diabetes mellitus, Tuberculosis, Toxoplasmosis and Th1 and Th2 cell differentiation, while the down-regulated genes were correlated with Renal cell carcinoma, Renin-angiotensin system, Thiamine metabolism and Thyroid cancer (Fig. 9C and D).