The corresponding volcano map and heatmap were respectively displayed in Supplementary Figure S1A and B. The up- and down-regulated genes’ KEGG analysis were respectively presented in Supplementary Figure S1C and D, and it demonstrated that the DEGs were correlated with Systemic lupus erythematosus, Tuberculosis, Th17 cell differentiation, Type I diabetes mellitus, Viral myocarditis, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Renin-angiotensin system and Transcriptional misregulation in cancer. This evidence concerns the gene REN and cancer.