According to the predominant tau isoforms in the intracellular inclusions, tauopathies are classified as 3R-tauopathies (primarily consisting of tau protein with 3 MTBDs), 4R-tauopathies (primarily consisting of tau protein with 4 MTBDs), and those with 3R and 4R tau protein in an equal ratio (3R:4R tauopathies) [44]. Here, MAPT is linked to tauopathy.