TNF and Alzheimer disease: Furthermore, minocycline, a tetracycline antibiotic has attracted increasing attention for the treatment of neuropsychiatric disorders; in rat models of AD treated with Aβ1-42, minocycline administration has been associated with decreased depression-like behavior, accompanied by lower levels of the pro-inflammatory cytokines interleukin(IL)-1β and tumor necrosis factor (TNF)-α in the hippocampus of the animals [121].