Myeloid cells respond to cancer by activating IFN-I/IFNβ expression to regulate an anti-tumor immune response, but at the same time, tumor cells may use PD-L1 to activate PD-1-intrinsic inhibitory signaling in myeloid cells to shut down IFN-I expression and therefore function to evade cancer. Here, IFNB1 is linked to neoplasm.