Analysis of the mouse cd279 promoter regions by ChIP illustrated that after IFNβ and IFNΒCOL01 treatment, enrichment of irf2 increased in the promoter regions of the cd279 gene in −2000 to +2000 regions in RAW264.7 cells (Figure 5C) and in −2000 to 0, +1000 to +2000 regions in tumor-infiltrating CD11b+ cells (Figure 5D). This evidence concerns the gene PDCD1 and neoplasm.