Thus, the cGAS-STING pathway has been shown to regulate inflammation levels and the ehomeostasis of energy in obesity [77,78], in systemic lupus erythematosus [79,80], in tubular epithelial cells in a mouse model of chronic kidney disease [81] and in acute kidney injury [82,83]. The gene discussed is STING1; the disease is obesity due to melanocortin 4 receptor deficiency.