The results, presented in Figure 5, show that the activated form of cortactin (pTyr421) and TKS5 are present in the CAIX-positive (a marker of hypoxia), collagen-rich areas of IPF lungs, further suggesting the relevance of invadosome formation during in vivo fibrogenesis. The gene discussed is SH3PXD2A; the disease is idiopathic pulmonary fibrosis.