The results show a significant increase in the hypoxia-associated genes (HIF1A, ALDOC, EGLN1, SLC2A1, ENO1, CA9 6/19/24 3:53:00 PM); fibrosis-associated genes (COL3A1, FAP, HAS2, PDGFRB); and genes linked to invadosome formation (SH3PXD2B, SH3PXD2A, MMP14, SVIL, AFAP1, SYNJ2, ACTR2) [28,29,30] in IPF patients with increasing disease severity compared to healthy subjects (Figure 3A–C). This evidence concerns the gene ENO1 and idiopathic pulmonary fibrosis.