To determine whether iron-induced cellular hyperproliferation is mediated through GLUT3 upregulation, we treated the hepatocellular carcinoma cell line HepG2 with iron in the presence or absence of small interfering RNA (siRNA)-mediated GLUT3 gene silencing and assessed the expression of cell cycle markers and cell proliferation. Here, SLC2A3 is linked to hepatocellular carcinoma.