CD163 and neoplasm: Considering eHSP90α is a potent inducer of macrophage M2-polarization, we also noticed that HH01 treatment led to an obvious increase in tumor F4/80+ pan-macrophage levels but a reduction in CD163+ M2-macrophages, resulting in a significant decrease of the ratio of M2-macrophage to pan-macrophage (Figure 6B).