The secreted eHSP90α facilitates the interaction of its cell-surface receptors CD91 and TLR4 on macrophages, inducing tumor-promoting M2-polarization through the MyD88-IRAK complex-associated IKKα/β−NF-κB/IRF3 and JAK2/TYK2−STAT-3 signaling pathways [15]. Here, LRP1 is linked to neoplasm.