NOTCH1 and adenoid cystic carcinoma: Interestingly, the Notch-associated bHLH transcription factor HEY1 was also identified as a target DEG and showed the strongest downregulation amongst Notch signaling genes (Figure 7D, Data S08), despite being previously reported as a positively regulated NOTCH1 effector in adenoid cystic carcinoma cells [105].