Animal studies have discovered additional genes associated with PHPV, which include orthologs of EFNB2, EFNA5, SKI, BAX, BAK1, FZD5, ANGPT2, TP53, CDKNA2, CRYBA1, TGFB2, VEGFA, and NEO1 [87,88,89,90]. Here, FZD5 is linked to persistent hyperplastic primary vitreous.