Given the role of Tβ4 and Tβ10 in cancer progression, the Tβ4- and Tβ10-producing stromal cells of the tumor microenvironment appear an ideal target of future anti-cancer therapies aimed at halting the ability of tumor cells to migrate and create distant metastases through the blocking/inhibition of Tβ4 biological action. The gene discussed is TMSB10; the disease is cancer.