This finding suggests that the isoform-dependent formation of tau aggregates might determine the vulnerability of different brain cells in varied forms of tauopathy, and accordingly, these aggregates are transmitted to the interconnected regions, affecting the signature cell types [107], where AD-tau intracerebral injection leads to tau fibril formation mainly in neurons, whereas CBD-tau injection results in predominantly oligodendrocyte-specific tau aggregation [108]. The gene discussed is MAPT; the disease is Alzheimer disease.