MAPT and Alzheimer disease: In an experimental study led by Ferrer and co-workers, it was shown that unilateral injection of the sarkosyl-insoluble fraction of tau isolated from human AD, PART, PSP, PiD, and FTLD-P301L brains into the corpus callosum of WT mouse brain produced oligodendrocyte-specific coiled bodies and threads of tau, which could even spread to the contralateral corpus callosum of the brain.