In summary, these reports on the structural elucidation of varied and overlapping forms of tauopathies suggest that the presence or absence of specific repeat domains near the C-terminal end of tau determines the overall macromolecular structure of tau filaments in the brain and structural variability of tau may decide the cell-type-specific vulnerability of brain cells in tauopathies, and this unclear territory of tau pathology requires further investigations. Here, MAPT is linked to tauopathy.