APP and Alzheimer disease: In another study, conducted in 3xTg-AD mice harboring human presenilin-1 M146V (PS1M146V), human amyloid precursor protein Swedish mutation (APPSwe), and the P301L mutation of human tau (tauP301L) [13], it was found that expression of oligodendrocyte markers like MBP and CNPase was markedly decreased in the CA1 area of the hippocampus and layer II/III of the entorhinal cortex of 6-month-old 3xTg mice compared to age-matched non-Tg mice.