The most prevalent tauopathy is AD, whereas other tauopathies include frontotemporal dementia (FTD), chronic traumatic encephalopathy (CTE), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick’s disease (PiD), globular glial tauopathy (GGT), argyrophilic grain disease (AGD), etc. Interestingly, in the majority of these diseases tau aggregation and associated neurodegeneration happen sporadically and progressively with aging. The gene discussed is MAPT; the disease is Alzheimer disease.