EGFR and cancer: A number of studies have demonstrated that SeNPs can induce apoptotic death of cancer cells, for example, through the p53 and AKT pathways [26,27], by activating the mitochondria-mediated pathway [28,29], by inhibiting the EGFR (epidermal growth factor receptor)-mediated PI3K/AKT pathways and Ras/Raf/MEK/ERK and through activation of MAPK and the caspase-3 signaling pathway [30,31].