Since the IC50 for p38MAPK induction of cytoplasmic vacuolation in cancer cells is 31-times greater than their ability to inhibit PIKFYVE, their activity against cancer cells does not result from their ability to inhibit PIKFYVE, but from their ability to inhibit phosphorylation of the lysosomal LAMP2 protein [7]. The gene discussed is PIKFYVE; the disease is cancer.