Notably, RELN as an extracellular matrix protein with reduced expression in the brain of patients with autism, is involved in cell positioning, neuronal migration, and dendritic spine formation [29,54,55], processes impacted in our in vitro autism studies, exhibited a highly significant reduced expression along with increased expression of TGFB1 as well as TGFB2 in astrocytes. Here, TGFB2 is linked to autism.