IFI16 and autism: As shown in Figure 2K,L, we also found that IFI16 promoter DNA is hypomethylated (~40%, Mean ± SEM 1.1 ± 0.1 and 0.5 ± 0.1 in controls and autism, respectively, p = 0.003), but HAP1 promoter was hypermethylated in the postmortem brains of these patients (~60%, Mean ± SEM 1 ± 0.11 and 1.6 ± 0.2 in controls and autism, respectively, p = 0.04).