SPARC and neoplasm: This reduction in tumor weight is accompanied by the induction of a highly favorable gene expression profile in the fibroid xenografts, with reduced expression of cell cycle regulatory proteins, components of the ECM such as collagen and FN1, proinflammatory cytokines (IL6, IL1β, and TNFα), estrogen and progesterone receptor, growth, and angiogenic factors (PDGF, VEGFC, SPARC, and TDO2) and induction of two miRNAs with critical roles in fibroid pathogenesis (namely, miR-29c and miR-200c).