The orphan nuclear receptor (NR2F1) regulates tumor cell dormancy in head and neck squamous cell carcinoma (HNSCC) by coordinating the hypermethylation of H3 histone proteins (H3K27, H3K9, and H3K4), bounded to SOX9, RARβ, and CDK inhibitors to inhibit cell proliferation [48]. The gene discussed is ESRRB; the disease is head and neck squamous cell carcinoma.