Furthermore, a study that characterized HSP based on the thematic hallmarks of cancers found a surge in the TRAP1 (HSP75), DNAJA3 (TID1), and DNAJC19 (HSP40 C19 member) (HSP40 family proteins) genes across different cancers, proffering anti-apoptotic signals [190]. Here, DNAJA3 is linked to hereditary spastic paraplegia.