Remarkably, sprouting neovasculature tip niches show differential expression of the anti-angiogenic factors TGF-β1 and periostin that promote tumor growth in bone marrow and lung cancers, in contrast to thrombospondin-1 (TSP-1) expression in the mature lung and bone marrow microvascular niches that supports dormancy through its anti-angiogenic capacity [92]. This evidence concerns the gene THBS1 and lung cancer.