As a result of ARHI re-expression in ovarian cancers, there was inhibition of the PI3K/AKT/mTOR pathway, which led to Atg4 upregulation and its colocalization with cleaved microtubule-associated protein light chain 3 (LC3) in autophagosomes, allowing ovarian cancer cells to remain dormant. The gene discussed is DIRAS3; the disease is ovarian cancer.