PFKFB3 and breast cancer: Moreover, the differential expression of the 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkfb3) gene correlates with the induction of breast cancer stem cells’ (BCSCs) renewal, which fosters an aggressive breast cancer metastatic relapse, while its downregulation causes breast cancer dormancy.