Cross-sectional baseline quantitation of proteins included tTau, pTau181, Aβ42, Aβ40, NFL, and GFAP, while longitudinal neuropsychological measures comprised Mini-Mental State Examination (MMSE) and Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet (CERAD-TS) scores. The gene discussed is GFAP; the disease is Alzheimer disease.