CYP1B1 and skin cancer: In addition to CYP1A1, the Mukhtar group demonstrated in 2000 the induction of CYP1B1 in the human epidermis by UVB light [60], thus providing evidence of a possible role for both CyP1A1 and CyP1B1 in UV-induced skin cancers, as both activate pro-carcinogenic compounds and convert them into carcinogenic metabolites.