The tumor regression grade (TRG 0–3) was defined according to the percentage of viable cancer cells in the resected primary tumor (Figure 7G).[33] The High p‐eIF4E group had significantly higher major response rate (TRG0/1) compared to the Low p‐eIF4E group (Figure 7H), indicating that EBV‐positive GC patients with hyper‐phosphorylation level of eIF4E would gain better response from immunotherapy. This evidence concerns the gene EIF4E and cancer.