GLS and cancer: Glutamine synthetase (GS), also known as GLUL, is a pivotal metabolic enzyme in cancer cells,[34] facilitating the synthesis of glutamine from glutamate,[35] which enables cells to persevere under glutamine‐depleted conditions, thereby influencing cancer circuitry and cellular outcomes.[36] Our investigation revealed a positive association between GLS filament structure and ATF4 levels (Figure 3B).