We demonstrate an imbalance of HCN channel expression both in post mortem AD human hippocampus and in the hippocampus of Tau35 mice, a progressive tauopathy model that exhibits increased tau phosphorylation and deposition of abnormal tau species in the brain, albeit expressing only a minimal amount (≈ 7% of the total tau mRNA) of this human transgene.17 This evidence concerns the gene MAPT and Alzheimer disease.