To investigate this, we classified melanoma cell lines as either EP300/SOX10 co-amplified (>2 copies of both EP300/SOX10) or not co-amplified, treated them with the potent and specific p300 KAT inhibitor A-485, and probed for SOX10 and downstream SOX10 target genes, such as MITF and DCT (46). The gene discussed is SOX10; the disease is melanoma.