Although we have clearly demonstrated that p300 inhibition downregulates the expression of SOX10-activated genes and SOX10-dependent proliferation in human melanoma cells, it is important to recognize that SOX10 loss-of-function is also correlated with increased melanoma invasive capacity through upregulation of a metastatic transcriptional program that defines the undifferentiated phenotype (13). Here, SOX10 is linked to melanoma.