SOX10 and melanoma: To investigate this, we performed 6-day A-485 dose–response assays on a panel of melanoma cell lines with cells classified as EP300/SOX10 co-amplified/MITFhigh and EP300/SOX10 nonamplified/MITFlow cells (Fig. 5A) and found that co-amplified/MITFhigh cells were potently growth inhibited by A-485, relative to the nonamplified/MITFlow cells (Fig. 5A), including the acral melanoma cell lines CO79, YUHIMO, and YUSEEP.