In comparison with MaPR172H/− mammary tumors, the gene expression profile of MaP−/− mammary tumors enriched for Hallmark pathways that included allograft rejection, inflammatory response, MYC Targets V1, complement, protein secretion, and TNFA signaling via NFKB (FDR < 0.05; Supplementary Table S4; refs. 46, 64) GSEA utilizing the Reactome database revealed enriched proinflammatory cytokine signaling and other immune signatures, consistent with some of the pathways associated with the Hallmark analysis (FDR < 0.05; refs. 46, 65). The gene discussed is TNF; the disease is breast cancer.