Through unbiased clustering and nearest neighbor analysis, we identified six distinct CNs within the malignant mesothelioma TIME (Fig. 2D): CN1 (immune cell–enriched tumor), CN2 (CD8+ T cell–enriched stroma), CN3 (B and CD4+ T cell–enriched stroma), CN4 (macrophage-enriched stroma), CN5 (immune cell–depleted tumor), and CN6 (B and CD8+ T cell–depleted tumor). Here, CD4 is linked to neoplasm.